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Prevalence, Characteristics and Clinical Diagnosis of Maturity Onset Diabetes of the Young Due to Mutations in HNF1A, HNF4A, and Glucokinase: Results from the SEARCH for Diabetes in Youth.
Conclusions/Interpretation:In this systematic study of MODY in a large pediatric US diabetes cohort, unselected by referral pattern or family history, MODY was usually misdiagnosed and incorrectly treated with insulin. While many type 2 diabetes-like metabolic features were less common in the mutation-positive group, no single characteristic identified all patients with mutations. Clinicians should be alert to the possibility of MODY diagnosis, particularly in antibody negative youth with diabetes. PMID: 23771925 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - June 14, 2013 Category: Endocrinology Authors: Gilliam LK, Pihoker C, Ellard S, Hattersley AT, Dabelea D, Davis C, Dolan LM, Greenbaum CJ, Imperatore G, Lawrence JM, Marcovina SM, Mayer-Davis E, Rodriguez BL, Steck AK, Williams DE, for the SEARCH for Diabetes in Youth Study Group Tags: J Clin Endocrinol Metab Source Type: research

A silver lining for migraine sufferers?
In this study, which followed nearly 75,000 women for 10 years, women with active migraine were 20% to 30% less likely to develop type 2 diabetes over the course of the study than women with no history of migraine. In addition, if the migraine condition improved and the headaches lessened, the chances of developing diabetes went up. This supports the notion that migraine is protective against developing diabetes, and this is not simply a chance association. Headache specialists had long observed that their migraine patient populations did not develop diabetes as frequently as the general population, so this finding was not...
Source: Harvard Health Blog - March 27, 2019 Category: Consumer Health News Authors: Paul Rizzoli, MD Tags: Diabetes Headache Source Type: blogs

New Drug Offers Hope to Millions With Severe Migraines - The New York Times
The first medicine designed to prevent migraines was approved by the Food and Drug Administration on Thursday, ushering in what many experts believe will be a new era in treatment for people who suffer the most severe form of these headaches.The drug, Aimovig, made by Amgen and Novartis, is a monthly injection with a device similar to an insulin pen. The list price will be $6,900 a year, and Amgen said the drug will be available to patients within a week.Aimovig blocks a protein fragment, CGRP, that instigates and perpetuates migraines. Three other companies — Lilly, Teva and Alder — have similar medicines in the final...
Source: Psychology of Pain - May 18, 2018 Category: Anesthesiology Source Type: blogs

Circulating Insulin-Like Growth Factor  1 Levels and Migraine Risk: A Mendelian Randomization Study
ConclusionThis two-sample Mendelian randomization study showed that genetically determined increased IGF1 levels are causally associated with decreased migraine risk. Future randomized controlled trials are warranted to confirm the benefits of IGF1 administration on migraines.
Source: Neurology and Therapy - September 1, 2022 Category: Neurology Source Type: research

New Trends in Migraine Pharmacology: Targeting Calcitonin Gene –Related Peptide (CGRP) With Monoclonal Antibodies
Conclusion Migraine is a disabling and debilitating neurovascular painful condition representing more than 90% of cases of recurrent headache and toward which the tendency can be inherited (MacGregor, 2017). Divalproex sodium, sodium valproate, topiramate, metoprolol, propranolol, and timolol have proven strong, level A, evidence for migraine prevention (American Academy of Neurology and American Headache Society, 2015). However, all the classic oral preventative treatments including tricyclic antidepressants, beta blockers, 5-HT2 antagonists ergots and anti-epileptic drugs were not developed for migraine and provide 50% ...
Source: Frontiers in Pharmacology - April 8, 2019 Category: Drugs & Pharmacology Source Type: research

8 Health Risks of Untreated Depression
Medication side-effects can seem unbearable at times: dry mouth, nausea, dizziness, constipation. Certain prescriptions can also increase our risks for developing chronic conditions like thyroid disease and diabetes. Three years ago, I decided that the pills’ side-effects weren’t worth the relief they brought, so I slowly weaned off all my medication. I then plummeted into a severe depression that ended up taking a far greater toll on my health than the nuisance of my drugs. You may be justifiably concerned about how your mood stabilizer and antidepressant are altering your biochemistry, but also consider the grave con...
Source: World of Psychology - March 5, 2019 Category: Psychiatry & Psychology Authors: Therese J. Borchard Tags: Depression General Medications Antidepressant Cognitive Decline Diabetes Mood Stabilizer Source Type: blogs

Ashley: now pain-free and slender on the Wheat Belly lifestyle
Ashley turned her life and health around by following the Wheat Belly lifestyle. Not only is she now 60 pounds lighter, but has experienced dramatic relief from a list of health problems. I’ve been debating on posting my picture. But I want to share my story so bad! In September 2014, I weighed 211 pounds. I was miserable. My lab work had come back and at age 32 I had problems that I shouldn’t have. I was on so much medication. I had debilitating migraines, very high blood pressure, I was borderline type 2 diabetic and on 1500 mg of metformin. My back and joints hurt all over. I couldn’t stand or walk f...
Source: Wheat Belly Blog - March 4, 2015 Category: Cardiology Authors: Dr. Davis Tags: Wheat Belly Success Stories diabetes joint pain metformin migraine headaches pre-diabetes Weight Loss Source Type: blogs

TRPV1 and Migraines
Conclusion-the present findings indicate that insulin may activate TRPV1 receptors in the trigeminovascular system. Modified TRPV1 receptor function induced by insulin may also increase the sensitivity of both neural and vascular TRPV1 receptor for its agonists. Our data may provide a pathophysiological basis for the increased incidence of migraine in patients with hyperinsulin levels.
Source: Neuromics - January 21, 2022 Category: Neuroscience Source Type: news

Genes, Vol. 13, Pages 730: Glucose-Related Traits and Risk of Migraine & mdash;A Potential Mechanism and Treatment Consideration
Genes, Vol. 13, Pages 730: Glucose-Related Traits and Risk of Migraine—A Potential Mechanism and Treatment Consideration Genes doi: 10.3390/genes13050730 Authors: Md Rafiqul Islam Dale R. Nyholt Migraine and glucose-related (glycaemic) traits (fasting glucose, fasting insulin, and type 2 diabetes) are common and complex comorbid disorders that cause major economic and social burdens on patients and their families. Studies on the relationship between migraine and glucose-related traits have yielded inconsistent results. The purpose of this review is to synthesise and discuss the information from the avai...
Source: Genes - April 22, 2022 Category: Genetics & Stem Cells Authors: Md Rafiqul Islam Dale R. Nyholt Tags: Review Source Type: research

The Relationship Between Triglyceride Glucose Index and Migraine: A Cross-Section Study from the National Health and Nutrition Examination Survey (NHANES)
CONCLUSION: In conclusion, there was a linear relationship between the TyG index and migraine. A higher TyG index predicts a lower incidence of migraine, particularly in females and Mexican Americans. Meanwhile, there is no inflection point between the TyG index and migraine.PMID:37282647 | DOI:10.2174/1567202620666230606100652
Source: Current Neurovascular Research - June 7, 2023 Category: Neurology Authors: Yao Liu Xiaochuan Gao Lingmei Yuan Yanming Li Peiwei Hong Source Type: research

Was it something I ate? Understanding the bidirectional interaction of migraine and appetite neural circuits
Brain Res. 2021 Aug 21:147629. doi: 10.1016/j.brainres.2021.147629. Online ahead of print.ABSTRACTMigraine attacks can involve changes of appetite: while fasting or skipping meals are often reported triggers in susceptible individuals, hunger or food craving are reported in the premonitory phase. Over the last decade, there has been a growing interest and recognition of the importance of studying these overlapping fields of neuroscience fields, which has led to novel findings. The data suggest additional studies are needed to unravel key neurobiological mechanisms underlying the bidirectional interaction between migraine a...
Source: Brain Research - August 24, 2021 Category: Neurology Authors: Margarida Martins-Oliveira Isaura Tavares Peter J Goadsby Source Type: research

Diabetes type 2: Migraines reduce risk of condition by regulating insulin finds new study
DIABETES type 2 is a condition characterised by rising blood sugars and insulin resistance. A new study finds those who suffer with migraines have a significantly lowered risk of developing the condition whilst those who develop diabetes become less prone to migraines. How?
Source: Daily Express - Health - August 30, 2021 Category: Consumer Health News Source Type: news

Are Glucose and Insulin Metabolism and Diabetes Associated with Migraine? A Community-Based, Case-Control Study.
CONCLUSION: Insulin resistance seems to exist in individuals with both migraine and prediabetes, and there is a possible negative association between DM and migraine. PMID: 28738109 [PubMed - in process]
Source: Journal of Orofacial Pain - July 25, 2017 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research

Is Migraine Primarily a Metaboloendocrine Disorder?
AbstractPurpose of the ReviewThe goals of this review are to evaluate recent studies regarding comorbidity between migraine and different metabolic and endocrine disorders and to discuss the role of insulin resistance as a common pathogenetic mechanism of these diseases.Recent FindingsRecently, several studies showed that migraine is associated with insulin resistance, a condition in which a normal amount of insulin induces a suboptimal physiological response. All the clinical studies that used the oral glucose tolerance test to examine insulin sensitivity found that, after glucose load, there is in migraine patients a sig...
Source: Current Pain and Headache Reports - April 4, 2018 Category: Neurology Source Type: research

Cross-trait analyses identify shared genetics between migraine, headache, and glycemic traits, and a causal relationship with fasting proinsulin
AbstractThe co-occurrence of migraine and glycemic traits has long been reported in observational epidemiological studies, but it has remained unknown how they are linked genetically. We used large-scale GWAS summary statistics on migraine, headache, and nine glycemic traits in European populations to perform cross-trait analyses to estimate genetic correlation, identify shared genomic regions, loci, genes, and pathways, and test for causal relationships. Out of the nine glycemic traits, significant genetic correlation was observed for fasting insulin (FI) and glycated haemoglobin (HbA1c) with both migraine and headache, w...
Source: Human Genetics - February 20, 2023 Category: Genetics & Stem Cells Source Type: research